Cisplatin induced cardiotoxicity

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August undefined, 2024

WebMay 9, 2024 · Busulfan-induced pulmonary injury; Cardiotoxicity of cancer chemotherapy agents other than anthracyclines, HER2-targeted agents, and fluoropyrimidines ... et al. … WebOct 20, 2024 · Breast Milk mesenchymal stem cells (Br-MSCs) are a non-invasive, highly reproducible source of stem cells. Herein, we investigate Br-MSCs' role in cardiotoxicity induced by cisplatin.

Recombinant human erythropoietin prevents cisplatin-induced ...

WebSep 1, 2024 · Cisplatin-induced cardiotoxicity severely limits its clinical application as an antitumor drug and increases the risk of cardiovascular disease. Icariin (ICA), the main … WebThe current study aimed to investigate the curative role of semaglutide's against cisplatin- induced cardiotoxicity and its relation to mitochondrial functions, dynamics, biogenesis, apoptosis, and redox status pathways. The study included 30 male rats divided into three groups: control, cisplatin-induced cardiotoxicity, and cisplatin-induced ... camping in sand dunes national park

Exploring the Involvement of Gut Microbiota in Cancer Therapy …

WebApr 14, 2024 · While the exact mechanisms underlying the relationship between gut microbiota and chemotherapy-induced cardiotoxicity are not yet fully understood, these findings suggest that targeting the microbiome may be a promising strategy for mitigating the cardiovascular side effects of cancer treatment. ... observed that cisplatin, one of the ... WebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP … WebJan 10, 2011 · Cisplatin-induced cardiotoxicity Acetyl-l-carnitine DL-α-lipoic acid Silymarin Mitochondrial DNA Apoptosis 1. Introduction Cisplatin is one of the most remarkable successes in ‘the war on cancer’. Since the accidental discovery four decades ago, cisplatin has been widely used for chemotherapy. camping in santee sc

Modulation of Oxidative Stress by Ozone Therapy in the …

Activation of STING Pathway Contributed to Cisplatin-Induced …

WebDec 30, 2015 · El-Awady el-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Eur Eur J … WebIn Cisplatin group, cardiac muscle fibers appeared disorganized, disrupted or degenerated with pyknotic nuclei and showed a significant rise in the number of anti-P53 positive nuclei. Significant increments in the percent area of collagenous fibers and TNF-α immune-expression were observed. first year mazda miata was builtWebApr 4, 2024 · Hesperidin (HES) is an abundant and economical dietary bioflavonoid, and it has several pharmacological properties such as antioxidant activity and powerful cardiac protection. However, HES protection against cisplatin (CP)-induced cardiotoxicity and its mechanism have not been fully clarified. camping in san bernardino national forest

"WebOct 1, 2010 · The increase in MDA may be due to the formation of oxygen-free radicals during cisplatin-induced cardiotoxicity, which react with membrane lipids, proteins, and nucleic acids and can cause ... " - Cisplatin induced cardiotoxicity

Cisplatin induced cardiotoxicity

The Beneficial Effects of Sulfur-containing Amino Acids on ...

WebJan 10, 2011 · Abstract. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of cisplatin as an anti-tumoral drug. Our study … WebAug 17, 2024 · Cisplatin-induced cardiotoxicity has been reported to mainly include arrhythmia, acute myocardial infarction, supraventricular tachycardia, and atrial fibrillation …

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WebSecondary prevention of anthracycline-induced cardiotoxicity has also gathered quite some scientific interest. Beta-blockers, aldosterone antagonists, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, neurohormonal blocking drugs and implantable devices have and may still all be used. WebApr 7, 2024 · This present study investigated the protective effects of asperuloside (ASP) against cadmium-induced nephrocardiac toxicity. Rats were treated with 50 mg/kg of ASP for five weeks and CdCl 2 (5 mg ...

WebRats treated with rhEPO, simultaneously, before, or after Cisp injection, remarkably decreased DNA damage, highlighting an interesting cytoprotective strategy usingrhEPO against Cisp-induced liver and heart injuries. Cisplatin (Cisp) is one of the most effective chemotherapeutic agents. However, at higher doses, liver and heart injuries may occur. … WebQuercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway Authors Shih-Hao Wang 1 2 , Kun-Ling Tsai 3 4 , Wan-Ching Chou 3 , Hui-Ching Cheng 3 , Yu-Ting Huang 3 , Hsiu-Chung Ou 5 , Yun-Ching Chang 6 Affiliations

WebJul 27, 2016 · Take for example the side effects of anticancer treatments: just a few years ago, side effects such as cardiotoxicity and myelotoxicity often forced the interruption of life-saving treatments. ... Callejo and colleagues examined in depth the state of art of cisplatin-induced ototoxicity. In addition to peripheral neurotoxicity, cisplatin ... WebJun 1, 2013 · At present, no data is provided explaining the mechanism of NO in cisplatin-induced cardiotoxicity. It has been found that NO and its metabolites, including …

WebCisplatin-induced cardiotoxicity is rare, and the prevalence remains unknown. Jakubowski and Kemeny showed that cardiotoxicity occurs in 6% of the patients …

WebOct 20, 2024 · Study results showed that Cis explored acute cardiotoxicity evidenced by deteriorated cardiac indices, induction of oxidative stress, and inflammation with myocardium histological alterations.... camping in schoonloo drentheWebCardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats Despite their clinical benefits in cancer treatment, the deleterious effects on heart following chemo/radiotherapy are of increasing importance. first year maths worksheetWebHowever, it has a wide variety of side effects such as hepato, gastrointestinal, neuro, nephro, and cardiotoxicity (acute and/or chronic) th … The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity in experimental rats camping in scarborough with electric hook upWebApr 15, 2024 · Cisplatin is mostly used in combination with other chemotherapy drugs to overcome drug-resistance and reduce toxicity [reviewed in ( 95 )]. Cisplatin-based chemotherapy has been reported to cause cardiovascular diseases, particularly myocardial infarction and angina, in a range of 7–32% of patients ( 96) [reviewed in ( 97 )]. first year medicine anatomyWebDrug-induced cardiotoxicity limits or forbids further use of the implicated drugs. Such drugs that are currently available in the clinic include anti-tumor drugs (doxorubicin, cisplatin, trastuzumab, etc.), antidiabetic drugs (rosiglitazone and pioglitazone), and an antiviral drug (zidovudine). camping in sawtooth national parkWebIt may be induced by factors including direct toxicity, ion imbalance, heart infiltration and, in the case of neuroendocrine tumors, the influence of tumor excretions. Keywords: … first year mbbs syllabusWebNational Center for Biotechnology Information first year maths notes